Compound Information

Compound Name: 1-[N-(3-Aminopropyl)-N-(3-ammoniopropyl)]diazen-1-ium-1,2-diolate

Figure: DPTA/NO (also NOC-19) Structure

Category Information
Nickname: DPTA/NO (also NOC-19)
CAS Registry Number: 146724-95-0
Molecular Formula: C₆H₁₇N₅O₂
Molecular Weight: 191
Half-life at pH 7.4 and 37^oC: 3 h
Moles of NO/Mole of Compound: 2 in phosphate buffer
Solubility:
UV Spectrum

λ_max(nm):

ε(mM^-1cm^-1):

252 in 0.01 M NaOH

7.9
X-Ray Crystallographic Data:
Special Comments: A commercially available reagent for producing reliable fluxes of NO in aqueous solutions or culture media with a relatively prolonged half-life (about 3 hours). This compound is known to be commercially available.

Reference Type	Keywords	Reference	Text
Biological	Cytostasis	Mooradian, D. L.; Hutsell, T. C.; Keefer, L. K. Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro. J. Cardiovasc. Pharmacol. 1995 25, 674-678.	Pubmed Abstract
Chemical		Hrabie, J. A.; Klose, J. R.; Wink, D. A.; Keefer, L. K. New nitric oxide-releasing zwitterions derived from polyamines. J. Org. Chem. 1993, 58, 1472-1476.
Chemical		Keefer, L. K.; Nims, R. W.; Davies, K. M.; Wink, D. A. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996 268, 281-293.	Pubmed Abstract
Patent		Keefer, L. K.; Hrabie, J. A. Complexes of nitric oxide with polyamines. U.S. Patent 5,155,137, October 13, 1992.	Patent 5155137 Full Text
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