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  • Synthesis Core

Synthesis Core

Dr. Gary Pauly
  Dr. Gary Pauly

Dr. Yixin Xie
  Dr. Yixin Xie

Dr. Dina Sigano
  Dr. Dina Sigano

The Chemistry Support Group is a component of the Chemical Biology Laboratory. This facility provides synthetic chemistry resources and expertise to the NCI Intramural community.

The facility’s capabilities include:
  • Providing expertise, consultation and experience in areas of chemical synthesis and purification.
  • Providing custom synthesis and support for the development of small molecule tools or the synthesis of known ligands or probes which are not commercially available.
  • Synthesis of materials for pre-clinical investigations.
  • Support for small-molecule drug discovery through optimization of leads identified in high throughput screens.
  • Collaborative short-term sabbatical-type opportunities for post-doctoral fellows who wish to gain synthetic chemistry experience.

The Chemistry Support Group provides a means to access chemical technology for those groups within the NCI Intramural community which would not otherwise be capable of exploring these aspects of their research.