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Compound Information

Compound Name: O2-(2,4-Dinitrophenyl) 1-[4-(N,N-Diethylcarboxamido)piperazin-1-yl]diazen-1-ium-1,2-diolate

Compound

Figure: CB-3-100 Structure

  1. Category Information
  2. Nickname: CB-3-100
  3. CAS Registry Number: 749875-33-0
  4. Molecular Formula: C15H21N7O7
  5. Molecular Weight: 411
  6. Half-life at pH 7.4 and 37oC:
  7. Moles of NO/Mole of Compound:
  8. Solubility:
  9. UV Spectrum

          λmax(nm):

          ε(mM-1cm-1):      

    300 in ethanol

    12.7
  10. X-Ray Crystallographic Data:
  11. Special Comments:

Reference and Patent Information

Reference TypeKeywordsReferenceText
Biological  Liu, J.; Li, C.; Qu, W.; Leslie, E.; Bonifant, C. L.; Buzard, G. S.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P. Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation. Mol. Cancer Ther. 2004, 3 (6), 709-714. Pubmed Abstract
Chemical  Liu, J.; Li, C.; Qu, W.; Leslie, E.; Bonifant, C. L.; Buzard, G. S.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P. Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation. Mol. Cancer Ther. 2004, 3(6), 709-714. Pubmed Abstract
Patent  Saavedra, J. E.; Keefer, L. K.; Srinivasan, A.; Rice, W. G.; Ji, X.; Bogdan, C. O2-Arylated or O2-glycosated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates. U.S. Patent 6,610,660, August 26, 2003. Patent 6610660 Full Text
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