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Compound Information

Compound Name: O2-(ß-D-N-Acetylglucosaminyl) 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate

Compound

Figure: CV-166, also GlcNAC-PYRRO/NO Structure

  1. Category Information
  2. Nickname: CV-166, also GlcNAC-PYRRO/NO
  3. CAS Registry Number: 1037206-68-0
  4. Molecular Formula: C12H22N4O6 * 0.5 H2O
  5. Molecular Weight: 334.33
  6. Half-life at pH 7.4 and 37oC:
  7. Moles of NO/Mole of Compound:
  8. Solubility:
  9. UV Spectrum

          λmax(nm):

          ε(mM-1cm-1):      

    254 (Methanol)

    7.5
  10. X-Ray Crystallographic Data:
  11. Special Comments: Antileishmanial effect in iNOS-deficient macrophages with no cytotoxicity

Reference and Patent Information

Reference TypeKeywordsReferenceText
ChemicalPreparation Valdez, C. A.; Saavedra, J. E.; Showalter, B. M.; Davies, K. M.; Wilde, T. C.; Citro, M. L.; Barchi, J. J.; Deschamps, J. R.; Parrish, D.; El-Gayar, S.; Schleicher, U.; Bogdan, C.; Keefer, L. K. Hydrolytic Reactivity Trends Among Potential Prodrugs of the O2-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity. J. Med. Chem., 2008, 51 (13), 3961-3970. Pubmed Abstract
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