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Compound Information

Compound Name: Sodium 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate

Compound

Figure: PYRRO/NO Structure

  1. Category Information
  2. Nickname: PYRRO/NO
  3. CAS Registry Number: 191083-52-0
  4. Molecular Formula: C4H8N3O2.Na
  5. Molecular Weight: 153
  6. Half-life at pH 7.4 and 37oC: 2.8 sec
  7. Moles of NO/Mole of Compound: 2
  8. Solubility: Aqueous solution at high pH
  9. UV Spectrum

          λmax(nm):

          ε(mM-1cm-1):      

    252 in 0.01 M NaOH

    8.8
  10. X-Ray Crystallographic Data:
  11. Special Comments: Undergoes spontaneous hydrolysis to give NO.

Reference and Patent Information

Reference TypeKeywordsReferenceText
Chemical  Saavedra, J. E.; Billiar, T. R.; Williams, D. L.; Kim, Y.-M.; Watkins, S. C.; Keefer, L. K. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J. Med. Chem. 1997, 40 (13), 1947-1954. Pubmed Abstract Full Text Article
Chemical  Saavedra, J. E.; Srinivasan, A.; Bonifant, C. L.; Chu, J.; Shanklin, A. P.; Flippen-Anderson, J. L.; Rice, W. G.; Turpin, J. A.; Davies, K. M.; Keefer, L. K. The secondary amine/nitric oxide ion R2N[N(O)NO]- as nucleophile and leaving group in SNAr reactions. J. Org. Chem. 2001, 66 (9), 3090-3098. Pubmed Abstract Full Text Article
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