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Structural Biophysics Laboratory (SBL)
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Structural Biology Retreat, October 2015, brings together researchers from multiple disciplines across the Frederick and Bethesda campuses of NCI

Welcome

The Structural Biophysics Laboratory (SBL) is a multi-disciplinary laboratory that strives to understand the function and mechanism of action of proteins and nucleic acids in the biological processes associated with cancer biology. The main structural technique is nuclear magnetic resonance (NMR) spectroscopy, and the groups are also active in the use of small angle scattering methods (SAXS and SANS) and a variety of biophysical methods (mass-spectroscopy, calorimetry, light scattering, molecular spectroscopy, surface plasmon resonance (SPR)). The most recent development is recruitment of a PI specializing in X-ray crystallography and CryoEM. The groups are engaged in both advancing the state-of-the-art methodology in these areas and applying them in an integrated cooperation with biologists within the CCR.

Biophysics Resource
The Biophysics Resource (BR) is operated by the Structural Biophysics Laboratory (SBL). It is providing access to analytical instrumentation and any required assistance for researchers from the Center for Cancer Research in need of biophysical characterization and examination of systems subject to structural investigations. Read More...
SAXS Core Facility Section
The SAXS Core facility provides routine access to the synchrotron and in-house SAXS/WAXS instrument and expertise in experimental design, data collection, analysis and interpretation to CCR researchers, other NIH intramural researchers, and extramural academic researchers. Read More...
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What's New at SBL

Expansion to four PI groups & SAXS Core Read More...

SBL leads re-establishment of Structural Biology Retreat Read More...

The installation of Bruker 850 MHz instrument is complete. Read More...