For Post-docs & Students
Molecular Discovery Seminar Series
Frederick National Lab Distinguished Scientist Lecture Series
NCI-CCR Eminent Lecture Series
Chemical Insights into Biological Processes
Check back for future events!
Frederick National Lab Calendar
NCI at a Glance
Molecular Discover Seminar Series
All seminars are given at NCI-Frederick on Thursdays at 10:00am in Building 376, Conference Room 121.
Dustin Maly (Univ of Washington)
“Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”
Michael Rossmann (Purdue Univ)
“The Structure of Zika Virus”
Alexei Demchenko (Univ of Missouri, St Louis)
“From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis”
Ting Xu (Univ of California, Berkeley)
“Toward Protein/Peptide-based Functional Hybrid Materials”
Dennis Dougherty (California Institute of Technology)
Steven Zimmerman (Univ of Illinois, Urbana)
Targeting the DNA and RNA That Causes Disease Using Small Molecules and Polymers”
Eric Schmidt (Univ of Utah)
“Accessing novel structural and bioactivity classes of marine natural products”
Chris Vanderwal (Univ of California, Irvine)
“Synthesis Strategies to Address Bioactive Natural Product Families”
Phil Cole (Johns Hopkins Univ)
"Bivalent Approaches to Drug Discovery"
Bruce Armitage (Carnegie Mellon Univ)
“Fluorescence Imaging Reagents Based on RNA Aptamers, Synthetic Polymers and Fluorogenic Cyanine Dyes”
Mark Distefano (Univ of Minnesota)
“Protein Lipid Modification: New Chemistry and New Biology”
Gary Martin (Merck)
“Evolving NMR Capabilities: The Impact on What is Possible”
Bradley Smith (Univ of Notre Dame)
“Near-infrared Fluorescent Multivalent Molecular Probes for Biological Imaging”
“Structure and Function of DNA G-quadruplexes and Its Potential as Anticancer Drug Target”
John Magnani (GlycoMimetics)
“The design, evaluation and clinical development of novel glycomimetic drugs for inflammatory disease and cancer”
Dustin Maly (Univ of Washington)
“Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”
Eric Martin (Novartis)
"Profile-QSAR Gen 2: Deep learning Kinase IC
predictions for novel compounds as accurate as 4-pt IC
Michael Strano (Massachussetts Inst of Technology)
“Fluorescent Carbon Nanotube Sensor Arrays and CoPhMoRe Binding for Label Free Glycoprofiling”
Richard Houghten (Torrey Pines Inst for Molecular Studies)
“The Direct Phenotypic Screening in Mice Using Large and Chemically Diverse Combinatorial Libraries”
Ben Miller (Univ of Rochester)
“Altering Protein Recording with Synthetic RNA Binders in HIV and Beyond”
Alex Deiters (Univ of Pittsburgh)
“Optical Control of Biological Processes in Cells and Animals”
Dennis Discher (Univ of Pennsylvania)
“Macrophage Recognition of ‘Self’ for Nano-and Micro- applications against solid Tumors"
Susan Mooberry (Univ of Texas Health Science Center, San Antonio)
“Looking to Nature to Discover Effective Treatments for Triple Negative Breast Cancers”
Kwaku (Theodore) Dayie (Univ of Maryland)
"Custom Made Nucleotides for RNA NMR"
Rob Britton (Simon Fraser Univ)
“New Reactions and Strategies for Natural Product and Drug Synthesis”
David Piwnica-Worms (MD Anderson Cancer Ctr)
“Molecular Imaging Strategies for Dynamic High Throughput Screens”
Linda Baum (Univ of Cal – Los Angeles)
“Assembly of Glycan-lectin Lattices Creates Functional Microdomains on the Cell Surface”
Yitzhak Tor (Univ of Cal – San Diego)
“New Isomorphic Fluorescent Nucleosides for Studying RNA-based Processes”
Linda Hsieh Wilson (Cal Inst of Tech)
“Carbohydrate Signaling in Neurobiology and Cancer”
Kevin Gardner (City University of New York)
“Environmentally-controlled protein/protein interactions: Nature’s switches, scientists’ tools”
Glenn Prestwich (University of Utah)
"Clinical Biomaterials for Regenerative Medicine: From Bench to Business to Bedside"
Heran Darwin (New York University)
"Mycobacterium tuberculosis, proteasomes, pupylation and... plant hormones?"
Paul Thompson (University of Massachusettes Medical School)
"Picking the PADlock: Chemical Probes to Characterize PAD Biology"
Sean Brady (Rockefeller University)
"Watch where you step, there is new chemistry everywhere"
Patricia Clark (University of Notre Dame)
"Synonymous Codon Substitutions: Not So 'Silent' After All"
Sandra Lee (Merck, Inc)
"Discovery of Novel, Selective Spleen Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis"
Klaus Hahn (University of North Carolina – Chapel Hill)
"Protein engineering to image and control Rho family GTPase signaling in motility"
Paul Hergenrother (University of Illinois, Urbana-Champaign)
"Anticancer drug discovery, from simple and complex compounds"
James Bradner (Harvard Medical School/Dana Farber Cancer Institute)
"Chemical Modulation of Chromatin Structure and Function"
Roger Linington (University of California, Santa Cruz)
"Connecting Phenotype and Chemotype: Development of an Integrated Platform for the Direct Prediction of Natural Products Mode of Action"
Jianghong Rao (Stanford University)
"A biocompatible condensation reaction between cyanobenzothiazole and aminothiol and its application for molecular imaging"
Jen Prescher (University of California, Irvine)
"Expanding the imaging toolbox"
Milan Mrksich (Northwestern University)
"Combining Arrays and Mass Spectrometry for High Throughput Discovery in Biology"
Joel Collier (University of Chicago)
"Supramolecular Peptide Immunomodulators"
Samie Jaffrey (Cornell University)
"Imaging RNA and RNA biology using RNA mimics of green fluorescent protein"
Amy Rosenzweig (Northwestern University)
"Copper, natural products, and biological methane oxidation"
Luke Lavis (HHMI-Janelia Farms)
“Old Dyes, New Tricks: Building Better Fluorophores for Biology”
John Porco (Boston University)
“Chemical Synthesis and Biological Studies of Antitumor Natural Products”
Gregg Fields (Torrey Pines Inst. For Molecular Studies)
“Modulation of Cell Surface Proteolytic Activity”
Gary Sulikowski (Vanderbilt University)
“Synthesis and Study of Natural Products of Possible Relevance to Human Health”
Judith Frydman (Stanford University)
“Chaperone control of cellular proteostasis in health and disease”
Hening Lin (Cornell University)
“Sirtuins and novel protein posttranslational modifications”
Ron Schnaar (Johns Hopkins University)
“Glycan Recognition in the Control of Inflammation”
Magid Abou-Gharbia (Temple University)
“Discovery of innovative therapeutics: Today’s realities and tomorrow’s vision”
John MacMillan (UT Southwestern Medical Center)
“Integration of microbial natural products with high-content screening for cancer drug discovery”
Sam Gellman (University of Wisconsin)
“Mimicry of Protein Surfaces with Alpha/Beta-Peptide Foldamers”
David Fushman (University of Maryland)
“Deciphering the “Ubiquitin Code”: Synthesis and Structure-Function Analysis of Non-Canonical Polyubiquitin Chains”
Tom Kodadek (The Scripps Research Institute - Florida)
“Chemical Tools to Monitor and Manipulate the Proteome”
Anna Mapp (University of Michigan)
“Small Molecule Transcriptional Modulators”
Ryan Looper (University of Utah)
“New methods to access biomedically interesting guanidinium ion scaffolds”
Justin DuBois (Stanford University)
"Turning Toxins into Tools for the Study of Ion Channels"
Thomas Williamson (Merck, Inc)
"ADEQUATE: NMR Experiments With an Expanding Role in Structure Elucidation"
Angela Koehler (The Broad Institute)
“Small-molecule probe discovery for transcriptional regulators”
Chris Lima (MSKCC)
“Structural insights to post-translational modification by Ubiquitin and
Jeff Aube (University of Kansas)
Jon Thorson (University of Kentucky)
"New strategies and tools for natural product diversification and discovery"
Julia Kornfield (Cal Tech)
"Crosslinking of Ocular Tissues"
Ron Koder (City College NY)
"Protein Design Approaches to Cancer Therapies"
Bill Gerwick (UCSD - SIO)
"The Fabulous Natural Products of Marine Cyanobacteria: Structures, Biological Activities, Biosynthetic Pathways"
Derek Tan (MSKCC)
"Diversity and Design: New Chemical Probes for Biology and Medicine"
David Spiegel (Yale University)
“Using Small Molecules to Engineer and Explore Human Immunity”
John Toscano (Johns Hopkins University)
"Nitroxyl (HNO): Nitric Oxide's Neglected Sibling"
Jim Wells (UCSF)
"Challenging Targets: Reaching for High Hanging Fruit in Drug Discovery"
*NOTE: This seminar is on MONDAY
Phil Dawson (TSRI)
"Chemical Ligation: From Post-Translationally Modified Proteins to Nanoparticle Engineering"
Paul Hanson (University of Kansas)
"Phosphate-Tether Mediated Methods to Bioactive Natural Products and Analogs"
David Lawrence (UNC at Chapel Hill)
"Cells Are Poor Cuvette Models: Challenges and Prospects of Molecular Probes for Intracellular Biochemistry"
Peter Wipf (University of Pittsburgh)
"In Search of the Silver Bullet- Redefining the Academic Drug Discovery Trajectory"
Ted Molinski (UCSD)
"Marine Natural Products. Scope, Synthesis-Aided Discovery, and New Approaches"
Ben Shen (Scripps Florida)
"Natural Products Drug Discovery: Challenges and Opportunities"
Hai-Quan Mao (Johns Hopkins University)
"Controlled Condensation of DNA and Self-Assembled Polymer/DNA Micelles for Liver-Targeted Gene Delivery"
Carlito Lebrilla (UC - Davis)
"Quantitative Measurements of Protein Glycosylation in Diseases and Health"
Cheryl Arrowsmith (University of Toronto)
"Structural and Chemical Biology of Readers and Writers of the Histone Code"
Matt Bogyo (Stanford University)
"Probing Protease Function Using Small Molecules: Applications from Cancer to Malaria"
Kylie Walters (University of Minnesota)
"Targeting Proteins for Destruction"
Please note: This seminar will be at 11am instead of 10am.
Jiyong Hong (Duke University)
"Natural Product Synthesis at the Interface of Chemistry and Biology"
Chris Ireland (University of Utah)
"Antitumor Agents from Marine Organisms"
Matt Francis (University of California, Berkeley)
"New Chemical Methods for Site Selective Protein Modification"
Dan Kahne (Harvard University)
"How does a cell make more of itself"
Brad Moore (University of California, San Diego/Scripps Institution of Oceanography)
"Genomics-inspired Discovery and Bioengineering of Natural Product Drugs"
Darrell Irvine (Massachusetts Institute of Technology)
"New materials and new methods for cancer immunotherapy and vaccine delivery"
Bruce Yu (University of Maryland)
"Developing Imaging Agents for 19F MRI"
Pieter Dorrestein (University of California, San Diego)
"Translating Adaptive Metabolism with Imaging Mass Spectrometry"
Peter Andreana (Wayne State University)
"Targeting Cellular Immunity with Entirely Carbohydrate-based Constructs"
David Corey (University of Texas Southwest Medical Center)
"Controlling Gene Expression with Synthetic Nucleic Acids"
Scott Miller (Yale University)
"Diverse Peptide-Based Catalysis for Diversification of Biologically Interesting Scaffolds"
Don Engleman (Yale University)
"pH-Dependent Transmembrane Peptide Insertion: Mechanism and Uses in Drug Delivery and Tumor Imaging"
Henry Kopecek (University of Utah)
"Smart Biomaterials and Drug Delivery Systems"
NIH...Turning Discovery Into Health®
U.S. Department of Health and Human Services
National Institutes of Health
National Cancer Institute