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Molecular Discovery Seminar Series

Due to the COVID-19 pandemic, all seminars are given on Thursdays at 10:00 am via WebEx until further notice.

Fall 2020 Virtual Series

  • Sep 17Cliff Stains (Univ of Virginia)
    "Chemical Approaches for Interrogating Cellular Processes"
  • Sep 24Nir London (Weizmann Institute of Science)
    “From covalent inhibitors to covalent PROTACs”
  • Oct 08Alison Tebo (Janelia Research Campus)
    “Imaging Cellular Processes Using Chemical-Genetic Tools”
  • Oct 22Christian Olsen (Univ of Copenhagen)
    "Cyclic Peptides for Investigating Histone Deacetylase (HDAC) Enzymes and Bacterial Communication"
  • Oct 29*Christine Szymanski (Univ of Georgia)
    "Exploiting Protein N-glycosylation in Campylobacter"
    *Sponsored by the CBL Women in Chemistry
  • Nov 12Dorothea Fiedler (FMP-Berlin)
    "Inositol Pyrophosphates – Multimodal Messengers Interrogated with Chemical Tools”
  • Nov 19Rob Batey (Univ of Colorado)
    "Small molecule-RNA interactions from biology to application"
  • Dec 03Elisa Fadda (Maynooth Univ)
    "Functional role of the glycan shield in the activation of the SARS-CoV-2 S protein”

Spring 2020 Virtual Series

  • Apr 02Lingyin Li (Stanford Univ)
    “Understand the extracellular cGAMP-STING pathway and harness it to treat cancers”
  • May 28Christian P. R. Hackenberger (Humboldt Univ and FMP-Berlin)
    “The power of chemoselectivity: Functional protein-conjugates for intra- and extracellular targeting”
  • Jun 04Ali Tavassoli (Univ of Southampton)
    “Platforms for the generation and high-throughput screening of cyclic peptide libraries”
  • Jun 11Alison Narayan (Univ of Michigan)
    “Biocatalysis and complex molecule synthesis”
  • Jun 18Jeremy M. Baskin (Cornell University)
    “Chemical Tools that IMPACT Lipid Signaling”

All seminars are given at NCI-Frederick on Thursdays at 10:00am in the Building 549 Auditorium, unless otherwise stated.

Spring 2020

  • Jan 23Jaclyn Winter (Univ of Utah)
    "Developing Microorganisms for Drug Discovery"
  • Feb 13Brian Shoichet (Univ of California, San Fransicso)
    "Docking >500 million available molecules to discover new chemotypes with new biology"

Fall 2019

  • Sep 12Ron Raines (MIT)
    "Ghost Proteins"
  • Sep 26Yamuna Krishnan (Univ of Chicago)
    “Quantitative Chemical Imaging in Live Cells”
  • Oct 03Robert Cichewicz (Univ of Oklahoma)
    “Seeking the Forest for the Trees: Finding Patterns and Chemistry Encompassing 3,531,905 Square Miles of Fungal Habitat”
  • Oct 10Doug Johnson (Biogen)
    “Application of Chemical Biology Probes and Bioorthogonal Chemistry in Drug Discovery”
  • Oct 24Bobby Arora (New York Univ)
    "Rational Design Strategies for Targeting Protein-Protein Interactions in Cancer"
  • Nov 07Michael Cohen (Oregon Health & Science Univ)
    “Decoding Protein ADP-ribosylation Networks in Cells Using Chemistry-based Approaches"
  • Nov 21Eric Strieter (UMass-Amherst)
    "Uncovering the Cryptic Functions of a Deubiquitinase"
  • Dec 05*Kristi Kiick (Univ of Delaware)
    "Phase-Separating (POLY)Peptides in the Design of Advanced Biomaterials"
    *Sponsored by the CBL Women in Chemistry
  • Dec 12Mano Manoharan (Alnylam Pharmaceuticals)
    “Biometric Chemistry of Human RNAi Therapeutics”

Spring 2019

  • Mar 07Miguel Castanho (Univ of Lisbon, Portugal)
    “Membrane-targeting peptides: from antimicrobial to anticancer”
  • Mar 21Dirk Trauner (New York Univ)
    "Controlling Protein Levels and Function with Photopharmacology"
  • Apr 04Eric Kool (Stanford Univ)
    “Small Molecules for Study and Control of RNA”
  • Apr 25Rahul Kohli (Univ of Pennsylvania)
    “Capturing TET-mediated DNA demethylation in action”
  • May 09Dehua Pei (The Ohio State Univ)
    “Drugging “Undruggable” Targets with Macrocyclic Peptides”
  • May 23Kai Johnsson (Max Planck Institute)
    "Fluorescent and Bioluminescent Sensor Proteins"
  • May 30Hendrik Luesch (Univ of Florida)
    "Natural Products from Marine Cyanobacteria as Starting Points for Drug Discovery and Development"

Fall 2018

  • Sep 20Rick Wagner (University of Minnesota)
    "Non-Genetic Engineering of Cell-Cell Interactions for Cancer Immunotherapy and Beyond"
  • Sep 27Lou Charkoutian (Haverford University)
    “Capturing transient interactions of proteins involved in natural product biosynthesis”
  • Oct 04Jen Heemstra (Emory University)
    “Small-molecule detection and enantiopurity measurement using DNA-based sensors”
  • Oct 25Mary Kay Pflum (Wayne State University)
    "Histone Deacetylase Proteins: Inhibitor Design and Substrate Identification"
  • Nov 08*Laura Kiessling (Massachusetts Institute of Technology)
    “Probes of Dendritic Cell Lectins”
    *Sponsored by the CBL Women in Chemistry
  • Nov 29Kamil Godula (University of California, San Diego)
    “Chemical tools for tailoring glycan interactions at the cell-matrix interface”
  • Dec 06Sarah Slavoff (Yale University)
    "Translation and functions of small open reading frames"
  • Dec 13Marcy Waters (University of North Carolina)
    “New Tools for Studying Epigenetic Protein-Protein Interactions”

Spring 2018

  • Feb 15Minkui Luo (Memorial Sloan Kettering Cancer Center)
    "Chemical Interrogation of Protein Methyltransferases: Function, Inhibition and Mechanism”
  • Mar 01Michelle Arkin (Univ of California, San Francisco)
    "Tackling Challenging Drug Targets, a Biophysical Perspective"
  • Apr 19Karen Wooley (Texas A&M Univ)
    "Expanding the Scopes of Synthetic Organic and Polymer Chemistry"
  • May 03Matt Francis (Univ of California, Berkeley)
    "New Synthetic Tools for Making Protein-Based Material"
  • May 10Nadja Cech (Univ of NC at Greensboro)
    “Untargeted metabolomics to Identify Bioactive Natural Products: Getting from What’s here? to What matters?"
  • May 31David Chenoweth (Univ of Pennsylvania)
    "Design and synthesis of new chemical tools for probing, manipulating, and imaging biological systems"

Fall 2017

  • Sep 14Brian Bachmann (Vanderbilt Univ)
    "Discovery of primary tumor cell selective effector molecules using single cell multiplexed activity metabolomics"
  • Sep 21Sam Achilefu (Washington Univ in St. Louis)
    “Light-Mediated Cancer Imaging and Treatment”
  • Oct 05M.G. Finn (Georgia Tech)
    “Click Reactions and Protein Nanoparticles: Building Functional Structures with Chemistry and Molecular Biology”
  • Nov 02Sid Hecht (Arizona State Univ)
    “Protein synthesis with Non-proteinogenic Alpha and Non-alpha Amino Acids”
  • Nov 09Catherine Leimkuhler Grimes (Univ of Delaware)
    "Breaking down Bacterial Cell Walls to Understand Inflammation"
  • Nov 16John Denu (Univ of Wisconsin, Madison)
    "How Metabolism Informs the Epigenome"
  • Nov 30Paola Castaldi (AstraZeneca)
    “Chemical Biology Strategies Applied to Drug Discovery”
  • Dec 07Bing Xu (Brandeis Univ)
    “Enzyme-Instructed Peptidic Nanostructures for Selectively Inhibiting Cancer Cells”

Spring 2017

  • Jan 12Dustin Maly (Univ of Washington)
    “Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”
  • Mar 23Michael Rossmann (Purdue Univ)
    “The Structure of Zika Virus”
  • Mar 30Alexei Demchenko (Univ of Missouri, St Louis)
    “From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis”
  • Apr 13Ting Xu (Univ of California, Berkeley)
    “Toward Protein/Peptide-based Functional Hybrid Materials”
  • Apr 20Dennis Dougherty (California Institute of Technology)
    “High-Precision Studies of Drug-Receptor Interactions in the Nicotinic Receptor”
  • Apr 27Steven Zimmerman (Univ of Illinois, Urbana)
    Targeting the DNA and RNA That Causes Disease Using Small Molecules and Polymers”
  • May 04 Eric Schmidt (Univ of Utah)
    “Accessing novel structural and bioactivity classes of marine natural products”
  • May 11Chris Vanderwal (Univ of California, Irvine)
    “Synthesis Strategies to Address Bioactive Natural Product Families”

Fall 2016

  • Sep 8Phil Cole (Johns Hopkins Univ)
    "Bivalent Approaches to Drug Discovery"
  • Sep 29Bruce Armitage (Carnegie Mellon Univ)
    “Fluorescence Imaging Reagents Based on RNA Aptamers, Synthetic Polymers and Fluorogenic Cyanine Dyes”
  • Oct 6Mark Distefano (Univ of Minnesota)
    “Protein Lipid Modification: New Chemistry and New Biology”
  • Oct 20Gary Martin (Merck)
    “Evolving NMR Capabilities: The Impact on What is Possible”
  • Oct 27Bradley Smith (Univ of Notre Dame)
    “Near-infrared Fluorescent Multivalent Molecular Probes for Biological Imaging”
  • Nov 3Danzhou Yang
    “Structure and Function of DNA G-quadruplexes and Its Potential as Anticancer Drug Target”
  • Nov 10John Magnani (GlycoMimetics)
    “The design, evaluation and clinical development of novel glycomimetic drugs for inflammatory disease and cancer”
  • Nov 17Dustin Maly (Univ of Washington)
    “Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”
  • Dec 8Eric Martin (Novartis)
    "Profile-QSAR Gen 2: Deep learning Kinase IC50 predictions for novel compounds as accurate as 4-pt IC50s"

Spring 2016


Fall 2015


Spring 2015


Fall 2014


Spring 2014


Fall 2013


Spring 2013


Fall 2012


Spring 2012


Fall 2011


Spring 2011


Fall 2010