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The Chemical Biology Laboratory (CBL) is a multidisciplinary laboratory that emphasizes chemical science at the interfaces of chemistry, biology and material science. The CBL conducts basic research that impacts cancer and AIDS diagnostics and treatment. The CBL evolved from the Laboratory of Medicinal Chemistry (LMC), a lab that had served as the focal point of chemical research within the NCI, historically steeped in the discovery and optimization of anticancer and anti-AIDS drugs. The CBL was formed to expand the role of chemistry and materials science in defining and manipulating the biological processes that impact cancer and AIDS with the ultimate goal of translating basic research discoveries into therapies.