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Dr. Joel Schneider

Dr. Joel Schneider
Peptide Design and Materials

Research Summary

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.
1 - 5 of 115 results

1)  Shi Junfeng, Fichman Galit, Schneider Joel P.
Enzymatic Control of the Conformational Landscape of Self-Assembling Peptides.
Angew. Chem. Int. Ed. Engl. 2018. [Journal]

2)  Thornburg Christopher C, Britt John R, Evans Jason R, Akee Rhone K, Whitt James A, Trinh Spencer K, Harris Matthew J, Thompson Jerell R, Ewing Teresa L, Shipley Suzanne M, Grothaus Paul G, Newman David J, Schneider Joel P, Grkovic Tanja, O'Keefe Barry R.
NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.
ACS Chem. Biol. 2018. [Journal]

3)  Gril Brunilde, Paranjape Anurag N, Woditschka Stephan, Hua Emily, Dolan Emma L, Hanson Jeffrey, Wu Xiaolin, Kloc Wojciech, Izycka-Swieszewska Ewa, Duchnowska Renata, Peksa Rafal, Biernat Wojciech, Jassem Jacek, Nayyar Naema, Brastianos Priscilla K, Hall O Morgan, Peer Cody J, Figg William D, Pauly Gary T, Robinson Christina, Difilippantonio Simone, Bialecki Emilie, Metellus Philippe, Schneider Joel P, Steeg Patricia S.
Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.
Nat Commun. 9: 2705, 2018. [Journal]

4)  Yamada Yuji, Chowdhury Ananda, Schneider Joel P, Stetler-Stevenson William G.
Macromolecule-Network Electrostatics Controlling Delivery of the Biotherapeutic Cell Modulator TIMP-2.
Biomacromolecules. 19: 1285-1293, 2018. [Journal]

5)  Nagarkar Radhika P, Miller Stephen E, Zhong Sheng, Pochan Darrin J, Schneider Joel P.
Dynamic protein folding at the surface of stimuli-responsive peptide fibrils.
Protein Sci. 27: 1243-1251, 2018. [Journal]