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Dr. Joel Schneider

Dr. Joel Schneider
Peptide Design and Materials

Research Summary

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.
1 - 5 of 108 results

1)  Ishikawa Ken, Medina Scott H, Schneider Joel P, Klar Amar J S.
Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide.
Cell Chem Biol. 24: 149-158, 2017. [Journal]

2)  Nagy-Smith Katelyn, Beltramo Peter J, Moore Eric, Tycko Robert, Furst Eric M, Schneider Joel P.
Molecular, Local, and Network-Level Basis for the Enhanced Stiffness of Hydrogel Networks Formed from Coassembled Racemic Peptides: Predictions from Pauling and Corey.
ACS Cent Sci. 3: 586-597, 2017. [Journal]

3)  Medina S.H., Schneider J.P..
Algar W.R., Dawson P., Medintz I.L., eds.
Chemical Ligations in the Design of Hydrogel Materials. In: Chemoselective and Bioorthogonal Ligation. Volume 16
Hoboken: Wiley-VCH Verlag GmbH & Co.; 2017. p. 497. [Book Chapter]

4)  Bahr Julian C, Robey Robert W, Luchenko Victoria, Basseville Agnes, Chakraborty Arup R, Kozlowski Hanna, Pauly Gary T, Patel Paresma, Schneider Joel P, Gottesman Michael M, Bates Susan E.
Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.
Oncotarget. 7: 69804-69815, 2016. [Journal]

5)  Schneider Joel.
Synthesis, peptoids and yellow pseudo peptides.
Biopolymers. 106: 632-3, 2016. [Journal]