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Dr. Joel Schneider



Dr. Joel Schneider
Peptide Design and Materials
301-846-5954

Research Summary

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.
PublicationsPatents
1 - 5 of 119 results

1)  Medina Scott H, Bush Brian, Cam Maggie, Sevcik Emily, DelRio Frank W, Nandy Kaustav, Schneider Joel P.
Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer.
Biomaterials. 202: 1-11, 2019. [Journal]

2)  Majumder Poulami, Baxa Ulrich, Walsh Scott T R, Schneider Joel P.
Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma.
Angew. Chem. Int. Ed. Engl. 57: 15040-15044, 2018. [Journal]

3)  Kapur Anshika, Medina Scott H, Wang Wentao, Palui Goutam, Schneider Joel P, Mattoussi Hedi.
Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide.
ACS Omega. 3: 12754-12762, 2018. [Journal]

4)  Kapur Anshika, Medina Scott H, Wang Wentao, Palui Goutam, Ji Xin, Schneider Joel P, Mattoussi Hedi.
Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide.
ACS Omega. 3: 17164-17172, 2018. [Journal]

5)  Shi Junfeng, Fichman Galit, Schneider Joel P.
Enzymatic Control of the Conformational Landscape of Self-Assembling Peptides.
Angew. Chem. Int. Ed. Engl. 57: 11188-11192, 2018. [Journal]