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Dr. Jordan L. Meier

Dr. Jordan L. Meier
Epigenetics and Metabolism

Research Summary

New Acetylation-Based Signaling Mechanisms

Acetyl-CoA is an essential cellular cofactor that links cellular metabolism with the regulation of gene activity by modulating the deposition of protein and nucleic acid modifications. A major focus of the laboratory is to integrate synthetic affinity probes with high-throughput proteomic approaches to discover and characterize new enzymatic and non-enzymatic acetylation mechanisms involved in malignancy. The goal of these studies is to expand the pharmacological map of epigenomic regulators involved in cancer, and to generate new knowledge for structure-based design, screening, and inhibitor development efforts.

Metabolic Regulation of Epigenetic Signaling

Recent studies have shown that many enzymes active in epigenetic mechanisms of genomic regulation are sensitive to the metabolic state of the cell. A second major aim of the lab is to understand the mechanisms by which metabolic perturbations influence genomic signaling mediated by chromatin modifying enzymes. Long term goals of this work include: 1) the discovery of biological mechanisms underlying oncometabolite-driven cancers, 2) the development of new diagnostics for cancers driven by metabolic mutations, and 3) the identification of small molecules which inhibit epigenetic modifications through metabolic disruption.