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Dr. Jordan L. Meier



Dr. Jordan L. Meier
Epigenetics and Metabolism
301-846-1929

Research Summary

Cofactor-Based Profiling of Chromatin Modifiers
Enzyme cofactors link cellular metabolism with the regulation of genome function through the activity of chromatin-modifying enzymes. A major focus of the laboratory is to integrate cofactor-based synthetic probes with high-throughput approaches for the proteomic, genomic, and structural characterization of chromatin modifiers. The goal of these studies is to expand the pharmacological map of epigenomic regulators involved in cancer, and to generate new knowledge for structure-based design, screening, and inhibitor development efforts.

Metabolic Regulation of Epigenetic Signaling
Recent studies have shown that many enzymes active in epigenetic mechanisms of genomic regulation are sensitive to the metabolic state of the cell. A second major aim of the lab is to understand the mechanisms by which metabolic perturbations influence genomic signaling mediated by chromatin modifying enzymes. Long term goals of this work include: 1) the discovery of biological mechanisms underlying oncometabolite-driven cancers, 2) the development of new diagnostics for cancers driven by metabolic mutations, and 3) the identification of small molecules which inhibit epigenetic modifications through metabolic disruption.
Publications
1 - 5 of 38 results

1)  Carrer Alessandro, Parris Joshua L D, Trefely Sophie, Henry Ryan A, Montgomery David C, Torres AnnMarie, Viola John M, Kuo Yin-Ming, Blair Ian A, Meier Jordan L, Andrews Andrew J, Snyder Nathaniel W, Wellen Kathryn E.
Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels.
J. Biol. Chem. 292: 3312-3322, 2017. [Journal]

2)  Kulkarni Rhushikesh A, Worth Andrew J, Zengeya Thomas T, Shrimp Jonathan H, Garlick Julie M, Roberts Allison M, Montgomery David C, Sourbier Carole, Gibbs Benjamin K, Mesaros Clementina, Tsai Yien Che, Das Sudipto, Chan King C, Zhou Ming, Andresson Thorkell, Weissman Allan M, Linehan W Marston, Blair Ian A, Snyder Nathaniel W, Meier Jordan L.
Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling.
Cell Chem Biol. 24: 231-242, 2017. [Journal]

3)  Zengeya Thomas T, Garlick Julie M, Kulkarni Rhushikesh A, Miley Mikayla, Roberts Allison M, Yang Youfeng, Crooks Daniel R, Sourbier Carole, Linehan W Marston, Meier Jordan L.
Co-opting a Bioorthogonal Reaction for Oncometabolite Detection.
J. Am. Chem. Soc. 138: 15813-15816, 2016. [Journal]

4)  Barajas Jesus F, Finzel Kara, Valentic Timothy R, Shakya Gaurav, Gamarra Nathan, Martinez Delsy, Meier Jordan L, Vagstad Anna L, Newman Adam G, Townsend Craig A, Burkart Michael D, Tsai Shiou-Chuan.
Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.
Angew. Chem. Int. Ed. Engl. 55: 13005-13009, 2016. [Journal]

5)  Montgomery David C, Garlick Julie M, Kulkarni Rhushikesh A, Kennedy Steven, Allali-Hassani Abdellah, Kuo Yin-Ming, Andrews Andrew J, Wu Hong, Vedadi Masoud, Meier Jordan L.
Global Profiling of Acetyltransferase Feedback Regulation.
J. Am. Chem. Soc. 138: 6388-91, 2016. [Journal]