1) Zhao XZ, Smith S, Maskell D, Metifiot M, Pye V, Fesen K, Marchand C, Pommier Y, Cherepanov P, Hughes SH, Burke TR, Jr.
Structure-guided optimization of HIV integrase strand transfer inhibitors.
Journal of Medicinal Chemistry. 60: 7315-7332, 2017.
In Press.
[Journal]
2) Métifiot M, Johnson BC, Kiselev E, Marler L, Zhao XZ, Burke TR, Marchand C, Hughes SH, Pommier Y.
Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
Nucleic Acids Res. 2016.
In Press.
[Journal]
3) Smith Steven J, Zhao Xue Zhi, Burke Terrence R, Hughes Stephen H.
HIV-1 integrase inhibitors that are broadly effective against drug-resistant mutants.
Antimicrob. Agents Chemother. 2018.
[Journal]
4) Smith Steven J, Zhao Xue Zhi, Burke Terrence R, Hughes Stephen H.
Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.
Retrovirology. 15: 37, 2018.
[Journal]
5) Boyer Paul L, Smith Steven J, Zhao Xue Zhi, Das Kalyan, Gruber Kevin, Arnold Eddy, Burke Terrence R, Hughes Stephen H.
Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.
J. Virol. 92, 2018.
[Journal]
1) Burke TR, King CR, Yao ZR (submitted in 1999) Acylated Oligopeptide Derivatives Having Cell Signal Inhibiting Activity.
Patent pending: 09/236,160 (US application).
2) Burke TR, Lin ZR, Neamati NR, Pommier YR, Zhao HR (submitted in 1999) Acetylated And Related Analogues Of Chicoric Acid As Hiv-1 Integrase Inhibitors.
Patents pending: PCT/US00/04608 (PC application); 60/121,127 (US application).
3) Bottaro DP, Atabey NP, Breckenridge DP, Burke TP, Gao YP, Yao ZP (submitted in 1999) Inhibition Of Cell Motility And Angiogenesis.
Patent pending: 60/221,525 (US application).
4) Pommier Y, Burke T, Neamati N, Zhaiwai L (submitted in 1999) Hydrazide Inhibitors Of Hiv-1 Integrase.
Patents pending: PCT/US00/06361 (PC application); 60/124,302 (US application).
5) Bottaro DP, Atabey NP, Breckenridge DP, Burke TP, Gao YP, Yao ZP (submitted in 1999) Inhibition Of Cell Motility And Angiogenesis By Inhibitors Of The Grb2 Sh2-domain.
Patents pending: 00992431.7 (ES application); 00992431.7 (FR application); 00992431.7 (GB application); 00992431.7 (IT application); 531405/2001 (JP application); 00992431.7 (CH application); 00992431.7 (DE application).